B.C.G. Dissemination in Congenital Hypogammaglobulinaemia

Pneumocystis Carinii Pneumonia and Congenital Hypogammaglobulinaemia.

A type of pneumonia due to the protozoon Pneumocystis carinii has been recognized in Europe for many years. There is frequent association with interstitial plasma cell pneumonia. Premature infants and debilitated full-term infants are chiefly affected, with peak incidence of infection occurring between 6 weeks and 4 months (Gajdusek, 1957). In recent years sporadic cases have been reported in G...

Pathogenesis of hypogammaglobulinaemia with thymoma and late-onset hypogammaglobulinaemia.

Mechanisms in secondary hypogammaglobulinaemia.

Hypogammaglobulinaemia refers to the low levels of circulating antibodies associated with a decreased gammaglobulin zone on electrophoresis. Since IgG is the predominant immunoglobulin a deficiency of it will most readily affect the gammaglobulin zone. Deficiencies of IgA and IgM will not necessarily result in a visual decrease in the latter. For practical purposes the clinically important stat...

Failure of intraventricular gammaglobulin and alpha interferon for persistent encephalitis in congenital hypogammaglobulinaemia.

A boy with congenital hypogammaglobulinaemia died at the age of 12 years after a viral meningoencephalitis of two and a half years duration due to an untypable picornavirus. He had received intravenous immunoglobulin every four weeks from the time of the start of immunoglobulin replacement treatment at the age of 3 years. The encephalitis did not respond to high dose intravenous gammaglobulin (...

Acquired hypogammaglobulinaemia and sarcoidosis.

A syndrome has been described in which hypogammaglobulinaemia is associated with splenomegaly and haemolytic anaemia and also non-caseating granulomata in lymph nodes, liver, spleen and skin. This report describes a patient with this syndrome who in addition had a positive Kveim and elevated serum angiotensin converting enzyme (SACE), suggesting the diagnosis of sarcoidosis.